GATEVIEW: A multi-omics analysis resource for Gene features of virus receptors within human tissues and single cells

The first and key step for virus to invade host is binding to the receptors genes on cell surface. Therefore, a comprehensive analysis of the receptors characteristics is critical to understand the the laws and mechanisms of virus invasion. Herein, we established GateView: a resource for gene features analysis of virus receptors within human tissues and single-cells. We collected 106 human viruses and their corresponding 74 receptor genes interaction relationship, then systematically evaluated the characteristics of receptors based on DNA, RNA ,and protein levels. The functions of receptor genes in cells, their expression levels in population of different genders, ages, and the effects of smoking, chronic diseases, as well as 33 different types of cancers on them are integrated into GateView. We developed tools to analysis the distribution of receptor genes in 30 normal tissues, 64 cell lines, and 39 single-cell sequencing data sets. In addition, Gateview illustrated the changes of receptor genes during fetal development and the distribution of homologs among various species. Gateview is currently the most comprehensive data resource for analyzing the distribution characteristics of virus receptor genes, which provides broad usability for the study of the range of virus invading hosts, tissue tropism, population preference, drug treatment as well as the mechanism of mother-to-child transmission, virus pathogenic, co-infection, and other aspects. Lastly, we guarantee that GateView will be maintained for a minimum of 5 years.

GateView: A Multi-Omics Platform for Gene Feature Analysis of Virus Receptors within Human Normal Tissues and Tumors. Yang Sun, Zi-Liang Huang, Wen-Xin Chen, Yi-Feng Zhang, Hao-Tian Lei, Qiao-Juan Huang, Zhao-Rong Lun, Liang-Hu Qu, Ling-Ling Zheng*.